Assay Detail
Binding
CHEMBL806167
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Inhibition of [33P]-S1P binding to human Sphingosine 1-phosphate receptor 1 expressed on CHO cell membranes
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Potent S1P receptor agonists replicate the pharmacologic actions of the novel immune modulator FTY720.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 15 | 8.11 | 10.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL115554 | — | — | 1 | 10.00 |
| CHEMBL113344 | — | — | 1 | 9.80 |
| CHEMBL225155 | — | — | 1 | 9.80 |
| CHEMBL114606 | — | — | 1 | 9.55 |
| CHEMBL432067 | — | — | 1 | 9.12 |
| CHEMBL115713 | — | — | 1 | 8.32 |
| CHEMBL325198 | — | — | 1 | 8.08 |
| CHEMBL114584 | — | — | 1 | 8.06 |
| CHEMBL91283 | — | — | 1 | 7.85 |
| CHEMBL112655 | — | — | 1 | 7.85 |
| CHEMBL114976 | — | — | 1 | 7.82 |
| CHEMBL115714 | — | — | 1 | 7.77 |
| CHEMBL325050 | — | — | 1 | 6.15 |
| CHEMBL115131 | — | — | 1 | 5.77 |
| CHEMBL326346 | — | — | 1 | 5.72 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL115554 | — | IC50 | = | 0.1 | nM | 10.00 |
| CHEMBL113344 | — | IC50 | = | 0.16 | nM | 9.80 |
| CHEMBL225155 | — | IC50 | = | 0.16 | nM | 9.80 |
| CHEMBL114606 | — | IC50 | = | 0.28 | nM | 9.55 |
| CHEMBL432067 | — | IC50 | = | 0.76 | nM | 9.12 |
| CHEMBL115713 | — | IC50 | = | 4.8 | nM | 8.32 |
| CHEMBL325198 | — | IC50 | = | 8.4 | nM | 8.08 |
| CHEMBL114584 | — | IC50 | = | 8.7 | nM | 8.06 |
| CHEMBL91283 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL112655 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL114976 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL115714 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL325050 | — | IC50 | = | 710.0 | nM | 6.15 |
| CHEMBL115131 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL326346 | — | IC50 | = | 1900.0 | nM | 5.72 |