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Assay Detail

CHEMBL806228

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Functional
Inhibitory activity against SW-620 human colon adenocarcinoma cells was determined.
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type SW-620
Confidence 1 — Organism
Curated By Expert

Target

SW-620 (CHEMBL612262)
Type CELL-LINE
Organism Homo sapiens

Publication

Synthesis and structure-activity relationships of 7-substituted 3-(2, 6-dichlorophenyl)-1,6-naphthyridin-2(1H)-ones as selective inhibitors of pp60(c-src).
Thompson AM, Rewcastle GW, Boushelle SL, Hartl BG, Kraker AJ, Lu GH, Batley BL, Panek RL, Showalter HD, Denny WA.
J Med Chem (2000) 43 : 3134 -3147
PubMed 10956222 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 12 5.69 6.92

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL51283 1 6.92
CHEMBL106772 1 6.77
CHEMBL49120 PD-0166285 1.0 1 6.57
CHEMBL49596 1 5.58
CHEMBL108333 1 5.58
CHEMBL104414 1 5.37
CHEMBL107472 1 5.30
CHEMBL107277 1 5.17
CHEMBL299194 1 5.12
CHEMBL108013 1 5.12
CHEMBL106839 1 5.06
CHEMBL104244 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL51283 IC50 = 120.0 nM 6.92
CHEMBL106772 IC50 = 170.0 nM 6.77
CHEMBL49120 PD-0166285 IC50 = 270.0 nM 6.57
CHEMBL49596 IC50 = 2600.0 nM 5.58
CHEMBL108333 IC50 = 2600.0 nM 5.58
CHEMBL104414 IC50 = 4300.0 nM 5.37
CHEMBL107472 IC50 = 5000.0 nM 5.30
CHEMBL107277 IC50 = 6700.0 nM 5.17
CHEMBL299194 IC50 = 7500.0 nM 5.12
CHEMBL108013 IC50 = 7600.0 nM 5.12
CHEMBL106839 IC50 = 8700.0 nM 5.06
CHEMBL104244 IC50 > 25000.0 nM -