Assay Detail
Functional
CHEMBL806235
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TNF-alpha-induced IL-6 production in SW1353 cells
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | SW1353 |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Synthesis and pharmacological characterization of a potent, orally active p38 kinase inhibitor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 6.54 | 7.24 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL38625 | — | — | 1 | 7.24 |
| CHEMBL41310 | — | — | 1 | 7.06 |
| CHEMBL41723 | — | — | 1 | 7.02 |
| CHEMBL288663 | — | — | 1 | 6.79 |
| CHEMBL415679 | — | — | 1 | 6.77 |
| CHEMBL288891 | — | — | 1 | 6.63 |
| CHEMBL40166 | — | — | 1 | 6.50 |
| CHEMBL288812 | — | — | 1 | 6.49 |
| CHEMBL40138 | — | — | 1 | 6.23 |
| CHEMBL288889 | — | — | 1 | 5.97 |
| CHEMBL290971 | — | — | 1 | 5.96 |
| CHEMBL290982 | — | — | 1 | 5.76 |
| CHEMBL38548 | — | — | 1 | - |
| CHEMBL40020 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL38625 | — | IC50 | = | 57.0 | nM | 7.24 |
| CHEMBL41310 | — | IC50 | = | 87.0 | nM | 7.06 |
| CHEMBL41723 | — | IC50 | = | 95.0 | nM | 7.02 |
| CHEMBL288663 | — | IC50 | = | 162.0 | nM | 6.79 |
| CHEMBL415679 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL288891 | — | IC50 | = | 235.0 | nM | 6.63 |
| CHEMBL40166 | — | IC50 | = | 313.0 | nM | 6.50 |
| CHEMBL288812 | — | IC50 | = | 323.0 | nM | 6.49 |
| CHEMBL40138 | — | IC50 | = | 584.0 | nM | 6.23 |
| CHEMBL288889 | — | IC50 | = | 1060.0 | nM | 5.97 |
| CHEMBL290971 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL290982 | — | IC50 | = | 1750.0 | nM | 5.76 |
| CHEMBL38548 | — | IC50 | > | 2500.0 | nM | - |
| CHEMBL40020 | — | IC50 | > | 2500.0 | nM | - |