Assay Detail
Binding
CHEMBL806331
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In vitro inhibition of rat neuronal (synaptosomal) GABA uptake.
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Expert |
Publication
Glycine antagonists. Synthesis, structure, and biological effects of some bicyclic 5-isoxazolol zwitterions.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 5.70 | 5.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL307931 | — | — | 1 | 5.70 |
| CHEMBL150830 | — | — | 1 | - |
| CHEMBL309688 | — | — | 1 | - |
| CHEMBL292757 | — | — | 1 | - |
| CHEMBL309689 | — | — | 1 | - |
| CHEMBL74364 | — | — | 1 | - |
| CHEMBL305673 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL307931 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL150830 | — | IC50 | = | 160000.0 | nM | - |
| CHEMBL309688 | — | IC50 | = | 130000.0 | nM | - |
| CHEMBL292757 | — | IC50 | > | 300000.0 | nM | - |
| CHEMBL309689 | — | IC50 | > | 300000.0 | nM | - |
| CHEMBL74364 | — | IC50 | > | 300000.0 | nM | - |
| CHEMBL305673 | — | IC50 | > | 300000.0 | nM | - |