Assay Detail
Functional
CHEMBL806364
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Inhibitory activity against SKBR-3 cell line using MTT assay (ER-amplified erB2,mutant p53)
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | SK-BR-3 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Antitumor polycyclic acridines. 7. Synthesis and biological properties of DNA affinic tetra- and pentacyclic acridines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 6.69 | 7.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 7.70 |
| CHEMBL41700 | — | — | 1 | 7.70 |
| CHEMBL43 | AMSACRINE | 4.0 | 1 | 7.22 |
| CHEMBL43453 | — | — | 1 | 6.92 |
| CHEMBL41701 | — | — | 1 | 6.92 |
| CHEMBL41526 | — | — | 1 | 6.82 |
| CHEMBL44657 | ETOPOSIDE | 4.0 | 1 | 6.52 |
| CHEMBL43229 | — | — | 1 | 6.38 |
| CHEMBL38451 | — | — | 1 | 6.35 |
| CHEMBL41174 | — | — | 1 | 6.24 |
| CHEMBL41863 | — | — | 1 | 5.99 |
| CHEMBL291263 | — | — | 1 | 5.46 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL41700 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL43 | AMSACRINE | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL43453 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL41701 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL41526 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL44657 | ETOPOSIDE | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL43229 | — | IC50 | = | 420.0 | nM | 6.38 |
| CHEMBL38451 | — | IC50 | = | 450.0 | nM | 6.35 |
| CHEMBL41174 | — | IC50 | = | 580.0 | nM | 6.24 |
| CHEMBL41863 | — | IC50 | = | 1030.0 | nM | 5.99 |
| CHEMBL291263 | — | IC50 | = | 3450.0 | nM | 5.46 |