Assay Detail
Functional
CHEMBL806366
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of cell growth of SKBr3 cell lines using cell-based assay
38
Total Activities
38
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | SK-BR-3 |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
6-Substituted-4-(3-bromophenylamino)quinazolines as putative irreversible inhibitors of the epidermal growth factor receptor (EGFR) and human epidermal growth factor receptor (HER-2) tyrosine kinases with enhanced antitumor activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 38 | 7.79 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL419501 | — | — | 1 | 9.00 |
| CHEMBL414220 | — | — | 1 | 9.00 |
| CHEMBL328245 | — | — | 1 | 8.70 |
| CHEMBL2112370 | — | — | 1 | 8.70 |
| CHEMBL328977 | — | — | 1 | 8.70 |
| CHEMBL90595 | — | — | 1 | 8.70 |
| CHEMBL91925 | — | — | 1 | 8.70 |
| CHEMBL92731 | — | — | 1 | 8.70 |
| CHEMBL93386 | — | — | 1 | 8.70 |
| CHEMBL94061 | — | — | 1 | 8.70 |
| CHEMBL93784 | — | — | 1 | 8.70 |
| CHEMBL94066 | — | — | 1 | 8.52 |
| CHEMBL442754 | — | — | 1 | 8.52 |
| CHEMBL93783 | — | — | 1 | 8.52 |
| CHEMBL92961 | — | — | 1 | 8.40 |
| CHEMBL94068 | — | — | 1 | 8.40 |
| CHEMBL91811 | — | — | 1 | 8.40 |
| CHEMBL328704 | — | — | 1 | 8.22 |
| CHEMBL327838 | — | — | 1 | 8.05 |
| CHEMBL94109 | — | — | 1 | 8.00 |
| CHEMBL329856 | — | — | 1 | 7.96 |
| CHEMBL93537 | — | — | 1 | 7.92 |
| CHEMBL316127 | — | — | 1 | 7.89 |
| CHEMBL2112369 | — | — | 1 | 7.89 |
| CHEMBL285063 | — | — | 1 | 7.82 |
| CHEMBL91867 | — | — | 1 | 7.77 |
| CHEMBL94062 | — | — | 1 | 7.37 |
| CHEMBL91009 | — | — | 1 | 7.34 |
| CHEMBL92356 | — | — | 1 | 7.21 |
| CHEMBL93049 | — | — | 1 | 7.04 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL419501 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL414220 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL2112370 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL328977 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL90595 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL91925 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL92731 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL93386 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL94061 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL93784 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL328245 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL94066 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL93783 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL442754 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL91811 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL92961 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL94068 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL328704 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL327838 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL94109 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL329856 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL93537 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL316127 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL2112369 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL285063 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL91867 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL94062 | — | IC50 | = | 43.0 | nM | 7.37 |
| CHEMBL91009 | — | IC50 | = | 46.0 | nM | 7.34 |
| CHEMBL92356 | — | IC50 | = | 62.0 | nM | 7.21 |
| CHEMBL93049 | — | IC50 | = | 92.0 | nM | 7.04 |
| CHEMBL92882 | — | IC50 | = | 370.0 | nM | 6.43 |
| CHEMBL92902 | — | IC50 | = | 478.0 | nM | 6.32 |
| CHEMBL93754 | — | IC50 | = | 568.0 | nM | 6.25 |
| CHEMBL329642 | — | IC50 | = | 742.0 | nM | 6.13 |
| CHEMBL94123 | — | IC50 | = | 1017.0 | nM | 5.99 |
| CHEMBL93464 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL91748 | — | IC50 | = | 1756.0 | nM | 5.75 |
| CHEMBL92086 | — | IC50 | = | 2220.0 | nM | 5.65 |