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Assay Detail

CHEMBL806421

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Functional
Inhibition of Src-transformed cell proliferation
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Cell Type Src-transformed
Confidence 1 — Organism
Curated By Expert

Publication

7-Alkoxy-4-phenylamino-3-quinolinecar-bonitriles as dual inhibitors of Src and Abl kinases.
Boschelli DH, Wang YD, Johnson S, Wu B, Ye F, Barrios Sosa AC, Golas JM, Boschelli F.
J Med Chem (2004) 47 : 1599 -1601
PubMed 15027848 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 14 6.26 7.00

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL288441 BOSUTINIB 4.0 1 7.00
CHEMBL290921 1 7.00
CHEMBL42136 1 6.66
CHEMBL41465 1 6.64
CHEMBL290664 1 6.64
CHEMBL40557 1 6.44
CHEMBL290308 1 6.41
CHEMBL41633 1 6.29
CHEMBL43577 1 5.85
CHEMBL440847 1 5.80
CHEMBL296844 1 5.64
CHEMBL40912 1 5.60
CHEMBL291297 1 5.42
CHEMBL290398 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL288441 BOSUTINIB IC50 = 100.0 nM 7.00
CHEMBL290921 IC50 = 100.0 nM 7.00
CHEMBL42136 IC50 = 220.0 nM 6.66
CHEMBL41465 IC50 = 230.0 nM 6.64
CHEMBL290664 IC50 = 230.0 nM 6.64
CHEMBL40557 IC50 = 360.0 nM 6.44
CHEMBL290308 IC50 = 390.0 nM 6.41
CHEMBL41633 IC50 = 510.0 nM 6.29
CHEMBL43577 IC50 = 1400.0 nM 5.85
CHEMBL440847 IC50 = 1600.0 nM 5.80
CHEMBL296844 IC50 = 2300.0 nM 5.64
CHEMBL40912 IC50 = 2500.0 nM 5.60
CHEMBL291297 IC50 = 3800.0 nM 5.42
CHEMBL290398 IC50 > 10000.0 nM -