Assay Detail
Binding
CHEMBL806427
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Inhibition of recombinant human Src kinase
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Proto-oncogene tyrosine-protein kinase Src (CHEMBL267) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
7-Alkoxy-4-phenylamino-3-quinolinecar-bonitriles as dual inhibitors of Src and Abl kinases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 7.75 | 8.57 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL290921 | — | — | 1 | 8.57 |
| CHEMBL288441 | BOSUTINIB | 4.0 | 1 | 8.42 |
| CHEMBL42136 | — | — | 1 | 8.15 |
| CHEMBL41465 | — | — | 1 | 8.11 |
| CHEMBL40557 | — | — | 1 | 8.05 |
| CHEMBL290664 | — | — | 1 | 7.92 |
| CHEMBL41633 | — | — | 1 | 7.89 |
| CHEMBL43577 | — | — | 1 | 7.68 |
| CHEMBL290308 | — | — | 1 | 7.62 |
| CHEMBL440847 | — | — | 1 | 7.46 |
| CHEMBL40912 | — | — | 1 | 7.20 |
| CHEMBL296844 | — | — | 1 | 7.06 |
| CHEMBL291297 | — | — | 1 | 6.64 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL290921 | — | IC50 | = | 2.7 | nM | 8.57 |
| CHEMBL288441 | BOSUTINIB | IC50 | = | 3.8 | nM | 8.42 |
| CHEMBL42136 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL41465 | — | IC50 | = | 7.7 | nM | 8.11 |
| CHEMBL40557 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL290664 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL41633 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL43577 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL290308 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL440847 | — | IC50 | = | 35.0 | nM | 7.46 |
| CHEMBL40912 | — | IC50 | = | 63.0 | nM | 7.20 |
| CHEMBL296844 | — | IC50 | = | 87.0 | nM | 7.06 |
| CHEMBL291297 | — | IC50 | = | 230.0 | nM | 6.64 |