Assay Detail
Binding
CHEMBL806433
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Inhibition of Src protein tyrosine kinase
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Proto-oncogene tyrosine-protein kinase Src (CHEMBL267) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Pyrrolo[2,3-d]pyrimidines containing diverse N-7 substituents as potent inhibitors of Lck.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 5.99 | 7.38 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL47203 | — | — | 1 | 7.38 |
| CHEMBL44942 | — | — | 1 | 6.53 |
| CHEMBL48554 | — | — | 1 | 6.50 |
| CHEMBL296534 | — | — | 1 | 6.41 |
| CHEMBL47940 | — | — | 1 | 6.25 |
| CHEMBL296103 | — | — | 1 | 5.95 |
| CHEMBL45177 | — | — | 1 | 5.92 |
| CHEMBL297359 | — | — | 1 | 5.83 |
| CHEMBL47202 | — | — | 1 | 5.75 |
| CHEMBL297278 | — | — | 1 | 5.63 |
| CHEMBL431342 | — | — | 1 | 5.26 |
| CHEMBL416444 | — | — | 1 | 4.49 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL47203 | — | IC50 | = | 42.0 | nM | 7.38 |
| CHEMBL44942 | — | IC50 | = | 298.0 | nM | 6.53 |
| CHEMBL48554 | — | IC50 | = | 320.0 | nM | 6.50 |
| CHEMBL296534 | — | IC50 | = | 390.0 | nM | 6.41 |
| CHEMBL47940 | — | IC50 | = | 560.0 | nM | 6.25 |
| CHEMBL296103 | — | IC50 | = | 1120.0 | nM | 5.95 |
| CHEMBL45177 | — | IC50 | = | 1190.0 | nM | 5.92 |
| CHEMBL297359 | — | IC50 | = | 1470.0 | nM | 5.83 |
| CHEMBL47202 | — | IC50 | = | 1780.0 | nM | 5.75 |
| CHEMBL297278 | — | IC50 | = | 2360.0 | nM | 5.63 |
| CHEMBL431342 | — | IC50 | = | 5460.0 | nM | 5.26 |
| CHEMBL416444 | — | IC50 | = | 32340.0 | nM | 4.49 |