Assay Detail
Binding
CHEMBL806434
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Inhibition of Src protein tyrosine kinase activity with 1 mM ATP and biotinylated lck peptide
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Proto-oncogene tyrosine-protein kinase Src (CHEMBL267) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
A-420983: a potent, orally active inhibitor of lck with efficacy in a model of transplant rejection.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 7.15 | 7.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL47787 | — | — | 1 | 7.89 |
| CHEMBL431609 | — | — | 1 | 7.25 |
| CHEMBL43773 | — | — | 1 | 7.24 |
| CHEMBL314627 | — | — | 1 | 7.16 |
| CHEMBL431407 | — | — | 1 | 7.01 |
| CHEMBL295601 | — | — | 1 | 6.81 |
| CHEMBL297363 | — | — | 1 | 6.72 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL47787 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL431609 | — | IC50 | = | 56.0 | nM | 7.25 |
| CHEMBL43773 | — | IC50 | = | 57.0 | nM | 7.24 |
| CHEMBL314627 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL431407 | — | IC50 | = | 97.0 | nM | 7.01 |
| CHEMBL295601 | — | IC50 | = | 155.0 | nM | 6.81 |
| CHEMBL297363 | — | IC50 | = | 189.0 | nM | 6.72 |