Assay Detail
Binding
CHEMBL806436
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of Src protein tyrosine kinase
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Proto-oncogene tyrosine-protein kinase Src (CHEMBL267) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Bone-targeted pyrido[2,3-d]pyrimidin-7-ones: potent inhibitors of Src tyrosine kinase as novel antiresorptive agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 7.41 | 9.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL421024 | — | — | 1 | 9.52 |
| CHEMBL419360 | — | — | 1 | 8.70 |
| CHEMBL301612 | — | — | 1 | 7.80 |
| CHEMBL106442 | — | — | 1 | 7.11 |
| CHEMBL102801 | — | — | 1 | 6.70 |
| CHEMBL102217 | — | — | 1 | 6.12 |
| CHEMBL320374 | — | — | 1 | 5.89 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL421024 | — | IC50 | = | 0.3 | nM | 9.52 |
| CHEMBL419360 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL301612 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL106442 | — | IC50 | = | 77.0 | nM | 7.11 |
| CHEMBL102801 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL102217 | — | IC50 | = | 750.0 | nM | 6.12 |
| CHEMBL320374 | — | IC50 | = | 1300.0 | nM | 5.89 |