Assay Detail
Binding
CHEMBL806437
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Inhibition of Src protein tyrosine kinase
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Proto-oncogene tyrosine-protein kinase Src (CHEMBL267) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Pyrazolo[3,4-d]pyrimidines containing an extended 3-substituent as potent inhibitors of Lck -- a selectivity insight.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 7.34 | 7.46 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL44577 | — | — | 1 | 7.46 |
| CHEMBL45177 | — | — | 1 | 7.38 |
| CHEMBL45582 | — | — | 1 | 7.17 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL44577 | — | IC50 | = | 35.0 | nM | 7.46 |
| CHEMBL45177 | — | IC50 | = | 42.0 | nM | 7.38 |
| CHEMBL45582 | — | IC50 | = | 68.0 | nM | 7.17 |