Assay Detail
Functional
CHEMBL806525
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of c-Src transfected 3T3 cell proliferation
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Cell Type | 3T3 |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Proto-oncogene tyrosine-protein kinase Src (CHEMBL267) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery of a new class of anilinoquinazoline inhibitors with high affinity and specificity for the tyrosine kinase domain of c-Src.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 15 | 6.59 | 7.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL173799 | — | — | 1 | 7.22 |
| CHEMBL354145 | — | — | 1 | 7.05 |
| CHEMBL369360 | — | — | 1 | 7.00 |
| CHEMBL169186 | — | — | 1 | 6.96 |
| CHEMBL170984 | — | — | 1 | 6.92 |
| CHEMBL167890 | — | — | 1 | 6.52 |
| CHEMBL352977 | — | — | 1 | 6.51 |
| CHEMBL171125 | — | — | 1 | 6.51 |
| CHEMBL172450 | — | — | 1 | 6.51 |
| CHEMBL169643 | — | — | 1 | 6.47 |
| CHEMBL353070 | — | — | 1 | 6.42 |
| CHEMBL422564 | — | — | 1 | 6.35 |
| CHEMBL352992 | — | — | 1 | 6.28 |
| CHEMBL169797 | — | — | 1 | 6.16 |
| CHEMBL352877 | — | — | 1 | 5.94 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL173799 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL354145 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL369360 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL169186 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL170984 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL167890 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL352977 | — | IC50 | = | 310.0 | nM | 6.51 |
| CHEMBL171125 | — | IC50 | = | 310.0 | nM | 6.51 |
| CHEMBL172450 | — | IC50 | = | 310.0 | nM | 6.51 |
| CHEMBL169643 | — | IC50 | = | 340.0 | nM | 6.47 |
| CHEMBL353070 | — | IC50 | = | 380.0 | nM | 6.42 |
| CHEMBL422564 | — | IC50 | = | 450.0 | nM | 6.35 |
| CHEMBL352992 | — | IC50 | = | 530.0 | nM | 6.28 |
| CHEMBL169797 | — | IC50 | = | 690.0 | nM | 6.16 |
| CHEMBL352877 | — | IC50 | = | 1160.0 | nM | 5.94 |