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Assay Detail

CHEMBL806530

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibitory concentration of compound against S-Adenosyl-methionine decarboxylase (SAMDC) from rat liver
24
Total Activities
24
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 8 — Homologous single protein target
Curated By Expert

Target

S-adenosylmethionine decarboxylase proenzyme (CHEMBL3808)
Type SINGLE PROTEIN
Organism Rattus norvegicus

Publication

S-adenosylmethionine decarboxylase inhibitors: new aryl and heteroaryl analogues of methylglyoxal bis(guanylhydrazone).
Stanek J, Caravatti G, Capraro HG, Furet P, Mett H, Schneider P, Regenass U.
J Med Chem (1993) 36 : 46 -54
PubMed 8421290 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 24 6.57 8.22

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL151197 1 8.22
CHEMBL151222 1 8.22
CHEMBL151372 1 7.44
CHEMBL149797 1 7.21
CHEMBL150828 1 7.18
CHEMBL357754 1 7.08
CHEMBL151196 1 7.06
CHEMBL148996 1 7.05
CHEMBL150623 1 7.04
CHEMBL151001 1 6.92
CHEMBL150931 1 6.80
CHEMBL433513 1 6.75
CHEMBL151654 1 6.68
CHEMBL342495 1 6.62
CHEMBL151103 1 6.48
CHEMBL151255 1 6.28
CHEMBL150621 1 6.22
CHEMBL149976 1 6.17
CHEMBL216913 MITOGUAZONE 3.0 1 6.00
CHEMBL151724 1 5.51
CHEMBL346440 1 4.96
CHEMBL357298 1 4.70
CHEMBL147297 1 4.60
CHEMBL358674 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL151197 IC50 = 6.0 nM 8.22
CHEMBL151222 IC50 = 6.0 nM 8.22
CHEMBL151372 IC50 = 36.0 nM 7.44
CHEMBL149797 IC50 = 61.0 nM 7.21
CHEMBL150828 IC50 = 66.0 nM 7.18
CHEMBL357754 IC50 = 84.0 nM 7.08
CHEMBL151196 IC50 = 88.0 nM 7.06
CHEMBL148996 IC50 = 90.0 nM 7.05
CHEMBL150623 IC50 = 92.0 nM 7.04
CHEMBL151001 IC50 = 120.0 nM 6.92
CHEMBL150931 IC50 = 160.0 nM 6.80
CHEMBL433513 IC50 = 180.0 nM 6.75
CHEMBL151654 IC50 = 210.0 nM 6.68
CHEMBL342495 IC50 = 240.0 nM 6.62
CHEMBL151103 IC50 = 330.0 nM 6.48
CHEMBL151255 IC50 = 530.0 nM 6.28
CHEMBL150621 IC50 = 600.0 nM 6.22
CHEMBL149976 IC50 = 670.0 nM 6.17
CHEMBL216913 MITOGUAZONE IC50 = 1000.0 nM 6.00
CHEMBL151724 IC50 = 3100.0 nM 5.51
CHEMBL346440 IC50 = 11000.0 nM 4.96
CHEMBL357298 IC50 = 20000.0 nM 4.70
CHEMBL147297 IC50 = 25000.0 nM 4.60
CHEMBL358674 IC50 > 50000.0 nM -