Assay Detail
Functional
CHEMBL806561
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In vitro inhibition of growth of the human gastrointestinal adenocarcinoma cells SW480
11
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | SW480 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Improved synthesis and antitumor evaluation of 5,8-dideazaisofolic acid and closely related analogues.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 5.70 | 7.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL34259 | METHOTREXATE | 4.0 | 1 | 7.82 |
| CHEMBL423123 | — | — | 1 | 6.70 |
| CHEMBL36739 | — | — | 2 | 5.96 |
| CHEMBL3706582 | — | — | 1 | 5.80 |
| CHEMBL80135 | — | — | 1 | 5.32 |
| CHEMBL74659 | — | — | 1 | 5.30 |
| CHEMBL35936 | — | — | 1 | 5.00 |
| CHEMBL306826 | — | — | 1 | 4.08 |
| CHEMBL2114414 | — | — | 1 | - |
| CHEMBL77065 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL34259 | METHOTREXATE | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL423123 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL36739 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL3706582 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL36739 | — | IC50 | = | 4500.0 | nM | 5.35 |
| CHEMBL80135 | — | IC50 | = | 4800.0 | nM | 5.32 |
| CHEMBL74659 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL35936 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL306826 | — | IC50 | = | 84000.0 | nM | 4.08 |
| CHEMBL2114414 | — | IC50 | > | 300000.0 | nM | - |
| CHEMBL77065 | — | IC50 | = | 150000.0 | nM | - |