Assay Detail

CHEMBL806676

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Functional

In vitro cytotoxicity against SC3.2 cell proliferation after 18 hr exposure

ChEMBL ↗

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Target

SC-3 (CHEMBL614897) ↗

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Primary target SC-3

CHEMBL614897

Anchored from Assay target.

Protein identity SC-3

Disease frame Disease evidence pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Functional
Organism	Homo sapiens
Cell Type	SC-3
Confidence	1 — Organism
Curated By	Intermediate

Target

SC-3 (CHEMBL614897) ↗

Type	CELL-LINE
Organism	Mus musculus

Publication

A 2-nitroimidazole carbamate prodrug of 5-amimo-1-(chloromethyl)-3-[(5,6,7-trimethoxyindol-2-yl)carbony l]-1,2-dihydro-3H--benz[E]indole (amino-seco-CBI-TMI) for use with ADEPT and GDEPT.

Hay MP, Sykes BM, Denny WA, Wilson WR.
Bioorg Med Chem Lett (1999) 9 : 2237 -2242
PubMed 10465553 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	1	8.46	8.46

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL305925	—	—	1	8.46

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL305925	—	IC50	=	3.5	nM	8.46