Assay Detail
Functional
CHEMBL806686
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Tested for inhibitory concentration against SCC-VII murine squamous carcinoma cell line
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | SCC-7 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Synthesis and biological activity of N omega-hemiphthaloyl-alpha,omega- diaminoalkanoic acid analogues of aminopterin and 3',5-dichloroaminopterin.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 8.40 | 9.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL18155 | — | — | 1 | 9.05 |
| CHEMBL309160 | — | — | 1 | 8.80 |
| CHEMBL44919 | — | — | 1 | 8.40 |
| CHEMBL376180 | AMINOPTERIN | 2.0 | 1 | 8.40 |
| CHEMBL34259 | METHOTREXATE | 4.0 | 1 | 8.24 |
| CHEMBL119 | TRIMETREXATE | 4.0 | 1 | 8.20 |
| CHEMBL42819 | — | — | 1 | 7.72 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL18155 | — | IC50 | = | 0.89 | nM | 9.05 |
| CHEMBL309160 | — | IC50 | = | 1.6 | nM | 8.80 |
| CHEMBL44919 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL376180 | AMINOPTERIN | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL34259 | METHOTREXATE | IC50 | = | 5.8 | nM | 8.24 |
| CHEMBL119 | TRIMETREXATE | IC50 | = | 6.3 | nM | 8.20 |
| CHEMBL42819 | — | IC50 | = | 19.0 | nM | 7.72 |