Assay Detail
Functional
CHEMBL806706
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Compound was evaluated for the accumulation of cyclic AMP in SaOS-2 (human osteosarcoma) cells.
7
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | SAOS-2 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Dipeptide mimetics can substitute for the receptor activation domain resulting in highly potent analogues of hPTH(136)
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 7 | 8.78 | 9.07 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL276472 | — | — | 1 | 9.07 |
| CHEMBL438942 | — | — | 1 | 8.96 |
| CHEMBL439458 | — | — | 1 | 8.82 |
| CHEMBL440239 | — | — | 1 | 8.80 |
| CHEMBL2370336 | — | — | 1 | 8.64 |
| CHEMBL2370337 | — | — | 2 | 8.62 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL276472 | — | EC50 | = | 0.85 | nM | 9.07 |
| CHEMBL438942 | — | EC50 | = | 1.1 | nM | 8.96 |
| CHEMBL439458 | — | EC50 | = | 1.5 | nM | 8.82 |
| CHEMBL440239 | — | EC50 | = | 1.6 | nM | 8.80 |
| CHEMBL2370336 | — | EC50 | = | 2.3 | nM | 8.64 |
| CHEMBL2370337 | — | EC50 | = | 2.4 | nM | 8.62 |
| CHEMBL2370337 | — | EC50 | = | 3.0 | nM | 8.52 |