Assay Detail
Binding
CHEMBL806855
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Inhibitory concentration of compound against renin human plasma
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Plasma |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Analyses of ligand binding in five endothiapepsin crystal complexes and their use in the design and evaluation of novel renin inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 7.34 | 7.66 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL127931 | — | — | 1 | 7.66 |
| CHEMBL127208 | — | — | 1 | 7.60 |
| CHEMBL328965 | — | — | 1 | 6.77 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL127931 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL127208 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL328965 | — | IC50 | = | 170.0 | nM | 6.77 |