Assay Detail
Binding
CHEMBL806857
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Inhibitory concentration against human renin
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Renin inhibitors containing esters at the P2-position. Oral activity in a derivative of methyl aminomalonate.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 8.22 | 9.55 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL58153 | — | — | 1 | 9.55 |
| CHEMBL431751 | — | — | 1 | 6.89 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL58153 | — | IC50 | = | 0.28 | nM | 9.55 |
| CHEMBL431751 | — | IC50 | = | 130.0 | nM | 6.89 |