Assay Detail
Binding
CHEMBL806880
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Compound was tested in vitro for inhibitory activity against Herpes Simplex Virus type 2 ribonucleotide reductase
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Human alphaherpesvirus 2 |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Target
Ribonucleoside-diphosphate reductase RR1 (CHEMBL2095215) ↗| Type | PROTEIN COMPLEX GROUP |
| Organism | Homo sapiens |
Publication
Substituted penta- and hexapeptides as potent inhibitors of herpes simplex virus type 2 ribonucleotide reductase
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 5.20 | 6.35 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL19766 | — | — | 1 | 6.35 |
| CHEMBL19509 | — | — | 1 | 5.30 |
| CHEMBL436151 | — | — | 1 | 5.22 |
| CHEMBL19875 | — | — | 1 | 4.92 |
| CHEMBL19900 | — | — | 1 | 4.82 |
| CHEMBL430907 | — | — | 1 | 4.60 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL19766 | — | IC50 | = | 450.0 | nM | 6.35 |
| CHEMBL19509 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL436151 | — | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL19875 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL19900 | — | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL430907 | — | IC50 | = | 25000.0 | nM | 4.60 |