Assay Detail
Binding
CHEMBL807033
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Inhibition of sialidase (Flu A, 5 nM)
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Influenza A virus |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Neuraminidase (CHEMBL2051) ↗| Type | SINGLE PROTEIN |
| Organism | Influenza A virus (A/Puerto Rico/8/1934(H1N1)) |
Publication
Dihydropyrancarboxamides related to zanamivir: a new series of inhibitors of influenza virus sialidases. 1. Discovery, synthesis, biological activity, and structure-activity relationships of 4-guanidino- and 4-amino-4H-pyran-6-carboxamides.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 6.43 | 8.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL300461 | — | — | 1 | 8.40 |
| CHEMBL163966 | — | — | 1 | 8.22 |
| CHEMBL100991 | — | — | 1 | 7.60 |
| CHEMBL167390 | — | — | 1 | 7.40 |
| CHEMBL50254 | — | — | 1 | 6.75 |
| CHEMBL419710 | — | — | 1 | 6.35 |
| CHEMBL54149 | — | — | 1 | 6.30 |
| CHEMBL100677 | — | — | 1 | 5.62 |
| CHEMBL51451 | — | — | 1 | 4.72 |
| CHEMBL164112 | — | — | 1 | 4.72 |
| CHEMBL348821 | — | — | 1 | 4.70 |
| CHEMBL350948 | — | — | 1 | - |
| CHEMBL163885 | — | — | 1 | - |
| CHEMBL167747 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL300461 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL163966 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL100991 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL167390 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL50254 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL419710 | — | IC50 | = | 450.0 | nM | 6.35 |
| CHEMBL54149 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL100677 | — | IC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL51451 | — | IC50 | = | 19000.0 | nM | 4.72 |
| CHEMBL164112 | — | IC50 | = | 19000.0 | nM | 4.72 |
| CHEMBL348821 | — | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL350948 | — | IC50 | > | 390000.0 | nM | - |
| CHEMBL163885 | — | IC50 | = | 420000.0 | nM | - |
| CHEMBL167747 | — | IC50 | > | 480000.0 | nM | - |