Assay Detail
Binding
CHEMBL807035
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Inhibition of influenza A virus sialidase activity
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Influenza A virus |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Neuraminidase (CHEMBL2051) ↗| Type | SINGLE PROTEIN |
| Organism | Influenza A virus (A/Puerto Rico/8/1934(H1N1)) |
Publication
Dihydropyrancarboxamides related to zanamivir: a new series of inhibitors of influenza virus sialidases. 1. Discovery, synthesis, biological activity, and structure-activity relationships of 4-guanidino- and 4-amino-4H-pyran-6-carboxamides.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 21 | 7.52 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL98906 | — | — | 1 | 8.70 |
| CHEMBL73669 | — | — | 1 | 8.70 |
| CHEMBL433269 | — | — | 1 | 8.70 |
| CHEMBL317645 | — | — | 1 | 8.52 |
| CHEMBL99224 | — | — | 1 | 8.52 |
| CHEMBL101842 | — | — | 1 | 8.40 |
| CHEMBL317571 | — | — | 1 | 8.30 |
| CHEMBL318452 | — | — | 1 | 8.30 |
| CHEMBL354666 | — | — | 1 | 8.22 |
| CHEMBL353758 | — | — | 1 | 8.15 |
| CHEMBL167805 | — | — | 1 | 8.05 |
| CHEMBL295490 | — | — | 1 | 7.92 |
| CHEMBL352694 | — | — | 1 | 7.75 |
| CHEMBL1161504 | — | — | 1 | 6.68 |
| CHEMBL168147 | — | — | 1 | 6.54 |
| CHEMBL98838 | — | — | 1 | 6.50 |
| CHEMBL424387 | — | — | 1 | 5.38 |
| CHEMBL71078 | — | — | 1 | 4.92 |
| CHEMBL350207 | — | — | 1 | 4.72 |
| CHEMBL353063 | — | — | 1 | - |
| CHEMBL354279 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL98906 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL73669 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL433269 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL317645 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL99224 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL101842 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL317571 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL318452 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL354666 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL353758 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL167805 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL295490 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL352694 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL1161504 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL168147 | — | IC50 | = | 290.0 | nM | 6.54 |
| CHEMBL98838 | — | IC50 | = | 320.0 | nM | 6.50 |
| CHEMBL424387 | — | IC50 | = | 4200.0 | nM | 5.38 |
| CHEMBL71078 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL350207 | — | IC50 | = | 19000.0 | nM | 4.72 |
| CHEMBL353063 | — | IC50 | = | 130000.0 | nM | - |
| CHEMBL354279 | — | IC50 | > | 300000.0 | nM | - |