Assay Detail
Functional
CHEMBL807364
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In vitro antitumor activity against SCC25 human head and neck squamous carcinoma cells containing 10% fetal bovine serum
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | SCC-25 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Analogues of N alpha-(4-amino-4-deoxypteroyl)-N delta-hemiphthaloyl-L-ornithine (PT523) modified in the side chain: synthesis and biological evaluation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 8.10 | 9.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL18155 | — | — | 1 | 9.52 |
| CHEMBL42142 | — | — | 1 | 8.54 |
| CHEMBL100543 | — | — | 1 | 7.75 |
| CHEMBL34259 | METHOTREXATE | 4.0 | 1 | 7.57 |
| CHEMBL42109 | — | — | 1 | 7.14 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL18155 | — | IC50 | = | 0.3 | nM | 9.52 |
| CHEMBL42142 | — | IC50 | = | 2.9 | nM | 8.54 |
| CHEMBL100543 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL34259 | METHOTREXATE | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL42109 | — | IC50 | = | 72.0 | nM | 7.14 |