Assay Detail
Binding
CHEMBL807473
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inhibitory activity was evaluated against chymase from human heart.
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Synthesis, structure-activity relationships, and pharmacokinetic profiles of nonpeptidic alpha-keto heterocycles as novel inhibitors of human chymase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 3 | 7.25 | 7.88 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL247767 | CHYMOSTATIN | — | 1 | 7.88 |
| CHEMBL24647 | — | — | 1 | 7.11 |
| CHEMBL286319 | — | — | 1 | 6.76 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL247767 | CHYMOSTATIN | Ki | = | 13.1 | nM | 7.88 |
| CHEMBL24647 | — | Ki | = | 77.4 | nM | 7.11 |
| CHEMBL286319 | — | Ki | = | 174.0 | nM | 6.76 |