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Assay Detail

CHEMBL807534

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Competitive inhibitory activity against rat liver S-adenosyl-L-homocysteine hydrolase
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 8 — Homologous single protein target
Curated By Autocuration

Target

Adenosylhomocysteinase (CHEMBL3118)
Type SINGLE PROTEIN
Organism Rattus norvegicus

Publication

4',5'-unsaturated 5'-halogenated nucleosides. Mechanism-based and competitive inhibitors of S-adenosyl-L-homocysteine hydrolase.
Jarvi ET, McCarthy JR, Mehdi S, Matthews DP, Edwards ML, Prakash NJ, Bowlin TL, Sunkara PS, Bey P.
J Med Chem (1991) 34 : 647 -656
PubMed 1995889 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 1 5.01 5.01

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL609353 1 5.01

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL609353 Ki = 9700.0 nM 5.01