Assay Detail
Binding
CHEMBL807596
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Binding affinity to human sphingosine 1-phosphate receptor 5 expressed in CHO cells was determined by using [33P]-S1P as radioligand
27
Total Activities
26
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | CHO |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
The discovery of 3-(N-alkyl)aminopropylphosphonic acids as potent S1P receptor agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 27 | 7.30 | 9.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL118860 | — | — | 2 | 9.15 |
| CHEMBL117130 | — | — | 1 | 9.10 |
| CHEMBL115713 | — | — | 1 | 8.35 |
| CHEMBL117973 | — | — | 1 | 7.96 |
| CHEMBL115738 | — | — | 1 | 7.92 |
| CHEMBL334213 | — | — | 1 | 7.89 |
| CHEMBL119562 | — | — | 1 | 7.72 |
| CHEMBL118265 | — | — | 1 | 7.42 |
| CHEMBL119233 | — | — | 1 | 7.38 |
| CHEMBL325193 | — | — | 1 | 7.35 |
| CHEMBL424254 | — | — | 1 | 7.24 |
| CHEMBL119349 | — | — | 1 | 7.23 |
| CHEMBL432809 | — | — | 1 | 7.22 |
| CHEMBL116140 | — | — | 1 | 7.18 |
| CHEMBL119760 | — | — | 1 | 7.07 |
| CHEMBL421234 | — | — | 1 | 7.07 |
| CHEMBL118068 | — | — | 1 | 7.00 |
| CHEMBL325198 | — | — | 1 | 7.00 |
| CHEMBL117031 | — | — | 1 | 6.96 |
| CHEMBL1160958 | — | — | 1 | 6.85 |
| CHEMBL119516 | — | — | 1 | 6.70 |
| CHEMBL432632 | — | — | 1 | 6.70 |
| CHEMBL334144 | — | — | 1 | 6.35 |
| CHEMBL119257 | — | — | 1 | 6.23 |
| CHEMBL119110 | — | — | 1 | 6.08 |
| CHEMBL117569 | — | — | 1 | 5.82 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL118860 | — | IC50 | = | 0.7 | nM | 9.15 |
| CHEMBL117130 | — | IC50 | = | 0.8 | nM | 9.10 |
| CHEMBL115713 | — | IC50 | = | 4.5 | nM | 8.35 |
| CHEMBL118860 | — | IC50 | = | 5.5 | nM | 8.26 |
| CHEMBL117973 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL115738 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL334213 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL119562 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL118265 | — | IC50 | = | 38.0 | nM | 7.42 |
| CHEMBL119233 | — | IC50 | = | 42.0 | nM | 7.38 |
| CHEMBL325193 | — | IC50 | = | 45.0 | nM | 7.35 |
| CHEMBL424254 | — | IC50 | = | 57.0 | nM | 7.24 |
| CHEMBL119349 | — | IC50 | = | 59.0 | nM | 7.23 |
| CHEMBL432809 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL116140 | — | IC50 | = | 66.0 | nM | 7.18 |
| CHEMBL119760 | — | IC50 | = | 86.0 | nM | 7.07 |
| CHEMBL421234 | — | IC50 | = | 86.0 | nM | 7.07 |
| CHEMBL118068 | — | IC50 | = | 99.0 | nM | 7.00 |
| CHEMBL325198 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL117031 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL1160958 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL119516 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL432632 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL334144 | — | IC50 | = | 450.0 | nM | 6.35 |
| CHEMBL119257 | — | IC50 | = | 590.0 | nM | 6.23 |
| CHEMBL119110 | — | IC50 | = | 830.0 | nM | 6.08 |
| CHEMBL117569 | — | IC50 | = | 1500.0 | nM | 5.82 |