Assay Detail
Binding
CHEMBL807599
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Inhibition of [33P]-S1P binding to human Sphingosine 1-phosphate receptor 5 expressed on CHO cell membranes
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Potent S1P receptor agonists replicate the pharmacologic actions of the novel immune modulator FTY720.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 15 | 7.35 | 9.64 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL225155 | — | — | 1 | 9.64 |
| CHEMBL114606 | — | — | 1 | 9.11 |
| CHEMBL432067 | — | — | 1 | 8.74 |
| CHEMBL115554 | — | — | 1 | 8.35 |
| CHEMBL113344 | — | — | 1 | 8.01 |
| CHEMBL114976 | — | — | 1 | 7.57 |
| CHEMBL115713 | — | — | 1 | 7.48 |
| CHEMBL115714 | — | — | 1 | 7.14 |
| CHEMBL91283 | — | — | 1 | 7.12 |
| CHEMBL325198 | — | — | 1 | 7.00 |
| CHEMBL114584 | — | — | 1 | 6.64 |
| CHEMBL112655 | — | — | 1 | 6.62 |
| CHEMBL325050 | — | — | 1 | 6.00 |
| CHEMBL326346 | — | — | 1 | 5.48 |
| CHEMBL115131 | — | — | 1 | 5.36 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL225155 | — | IC50 | = | 0.23 | nM | 9.64 |
| CHEMBL114606 | — | IC50 | = | 0.77 | nM | 9.11 |
| CHEMBL432067 | — | IC50 | = | 1.8 | nM | 8.74 |
| CHEMBL115554 | — | IC50 | = | 4.5 | nM | 8.35 |
| CHEMBL113344 | — | IC50 | = | 9.8 | nM | 8.01 |
| CHEMBL114976 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL115713 | — | IC50 | = | 33.0 | nM | 7.48 |
| CHEMBL115714 | — | IC50 | = | 73.0 | nM | 7.14 |
| CHEMBL91283 | — | IC50 | = | 76.0 | nM | 7.12 |
| CHEMBL325198 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL114584 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL112655 | — | IC50 | = | 240.0 | nM | 6.62 |
| CHEMBL325050 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL326346 | — | IC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL115131 | — | IC50 | = | 4400.0 | nM | 5.36 |