Assay Detail
Binding
CHEMBL807663
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Inhibition of type-2 human steroid 5-alpha-reductase.
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
3-oxo-5-alpha-steroid 4-dehydrogenase 2 (CHEMBL1856) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
A comparison of steroidal and non-steroidal inhibitors of human steroid 5-reductase: New tricyclic aryl acid inhibitors of the type-1 isozyme
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 14 | 7.22 | 10.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL420020 | — | — | 1 | 10.10 |
| CHEMBL138225 | EPRISTERIDE | 2.0 | 1 | 9.70 |
| CHEMBL1627951 | — | — | 1 | 9.40 |
| CHEMBL76192 | — | — | 1 | 9.05 |
| CHEMBL143220 | — | — | 1 | 8.89 |
| CHEMBL2298601 | — | — | 1 | 8.70 |
| CHEMBL110001 | — | — | 1 | 7.52 |
| CHEMBL25081 | — | — | 1 | 6.58 |
| CHEMBL439804 | — | — | 1 | 5.80 |
| CHEMBL356780 | — | — | 1 | 5.60 |
| CHEMBL144346 | — | — | 1 | 5.00 |
| CHEMBL341625 | — | — | 1 | 5.00 |
| CHEMBL25578 | — | — | 1 | 5.00 |
| CHEMBL97266 | — | — | 1 | 4.70 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL420020 | — | Ki | = | 0.08 | nM | 10.10 |
| CHEMBL138225 | EPRISTERIDE | Ki | = | 0.2 | nM | 9.70 |
| CHEMBL1627951 | — | Ki | = | 0.4 | nM | 9.40 |
| CHEMBL76192 | — | Ki | = | 0.89 | nM | 9.05 |
| CHEMBL143220 | — | Ki | = | 1.3 | nM | 8.89 |
| CHEMBL2298601 | — | Ki | = | 2.0 | nM | 8.70 |
| CHEMBL110001 | — | Ki | = | 30.0 | nM | 7.52 |
| CHEMBL25081 | — | Ki | = | 260.0 | nM | 6.58 |
| CHEMBL439804 | — | Ki | = | 1600.0 | nM | 5.80 |
| CHEMBL356780 | — | Ki | = | 2500.0 | nM | 5.60 |
| CHEMBL144346 | — | Ki | = | 10000.0 | nM | 5.00 |
| CHEMBL341625 | — | Ki | = | 10000.0 | nM | 5.00 |
| CHEMBL25578 | — | Ki | = | 10000.0 | nM | 5.00 |
| CHEMBL97266 | — | Ki | = | 20000.0 | nM | 4.70 |