Assay Detail
Binding
CHEMBL807694
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Transcriptional activation in CV-1 cells expressing human Retinoic acid receptor RAR gamma
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CV-1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Retinoic acid receptor ligands based on the 6-cyclopropyl-2,4-hexadienoic acid.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 4 | 7.26 | 7.72 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL38 | TRETINOIN | 4.0 | 1 | 7.72 |
| CHEMBL89331 | — | — | 1 | 7.62 |
| CHEMBL705 | ALITRETINOIN | 4.0 | 1 | 7.30 |
| CHEMBL89581 | — | — | 1 | 6.41 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL38 | TRETINOIN | EC50 | = | 19.0 | nM | 7.72 |
| CHEMBL89331 | — | EC50 | = | 24.0 | nM | 7.62 |
| CHEMBL705 | ALITRETINOIN | EC50 | = | 50.0 | nM | 7.30 |
| CHEMBL89581 | — | EC50 | = | 391.0 | nM | 6.41 |