Assay Detail
Binding
CHEMBL807724
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Binding affinity towards retinoic acid receptor beta was determined using [3H]ATRA (5 nM) as radioligand
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Phenylcyclohexene and phenylcyclohexadiene substituted compounds having retinoid antagonist activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 9 | 7.87 | 8.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL349935 | — | — | 1 | 8.40 |
| CHEMBL165843 | — | — | 1 | 8.30 |
| CHEMBL349018 | — | — | 1 | 8.22 |
| CHEMBL358145 | — | — | 1 | 8.15 |
| CHEMBL38 | TRETINOIN | 4.0 | 1 | 7.96 |
| CHEMBL151870 | — | — | 1 | 7.70 |
| CHEMBL424190 | — | — | 1 | 7.57 |
| CHEMBL350485 | — | — | 1 | 7.46 |
| CHEMBL164176 | — | — | 1 | 7.06 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL349935 | — | Kd | = | 4.0 | nM | 8.40 |
| CHEMBL165843 | — | Kd | = | 5.0 | nM | 8.30 |
| CHEMBL349018 | — | Kd | = | 6.0 | nM | 8.22 |
| CHEMBL358145 | — | Kd | = | 7.0 | nM | 8.15 |
| CHEMBL38 | TRETINOIN | Kd | = | 11.0 | nM | 7.96 |
| CHEMBL151870 | — | Kd | = | 20.0 | nM | 7.70 |
| CHEMBL424190 | — | Kd | = | 27.0 | nM | 7.57 |
| CHEMBL350485 | — | Kd | = | 35.0 | nM | 7.46 |
| CHEMBL164176 | — | Kd | = | 87.0 | nM | 7.06 |