Assay Detail
Functional
CHEMBL807832
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Concentration required to inhibit the release of tumor necrosis factor -alpha (TNF-alpha) in THP-1 cellular assay.
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Cell Type | THP-1 |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Disintegrin and metalloproteinase domain-containing protein 17 (CHEMBL3706) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery of selective hydroxamic acid inhibitors of tumor necrosis factor-alpha converting enzyme.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 16 | 5.92 | 6.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL95718 | — | — | 1 | 6.85 |
| CHEMBL318005 | — | — | 1 | 6.75 |
| CHEMBL99283 | — | — | 1 | 6.66 |
| CHEMBL329302 | — | — | 1 | 6.52 |
| CHEMBL98770 | — | — | 1 | 6.40 |
| CHEMBL318860 | — | — | 1 | 6.36 |
| CHEMBL99103 | — | — | 1 | 6.36 |
| CHEMBL95305 | — | — | 1 | 6.26 |
| CHEMBL99318 | — | — | 1 | 5.54 |
| CHEMBL329232 | — | — | 1 | 5.46 |
| CHEMBL99120 | — | — | 1 | 5.39 |
| CHEMBL318484 | — | — | 1 | 5.07 |
| CHEMBL316725 | — | — | 1 | 4.82 |
| CHEMBL421009 | — | — | 1 | 4.39 |
| CHEMBL99547 | — | — | 1 | - |
| CHEMBL98304 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL95718 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL318005 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL99283 | — | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL329302 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL98770 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL318860 | — | IC50 | = | 440.0 | nM | 6.36 |
| CHEMBL99103 | — | IC50 | = | 440.0 | nM | 6.36 |
| CHEMBL95305 | — | IC50 | = | 550.0 | nM | 6.26 |
| CHEMBL99318 | — | IC50 | = | 2900.0 | nM | 5.54 |
| CHEMBL329232 | — | IC50 | = | 3500.0 | nM | 5.46 |
| CHEMBL99120 | — | IC50 | = | 4100.0 | nM | 5.39 |
| CHEMBL318484 | — | IC50 | = | 8600.0 | nM | 5.07 |
| CHEMBL316725 | — | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL421009 | — | IC50 | = | 41000.0 | nM | 4.39 |
| CHEMBL99547 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL98304 | — | IC50 | > | 5000.0 | nM | - |