Assay Detail
Functional
CHEMBL807900
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antagonist activity for Tachykinin receptor 1 as displacement of [3H]-Substance P in human IM-9 cells
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | IM-9 |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Synthesis and structure-activity relationships of CP-122,721, a second-generation NK-1 receptor antagonist.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 9.44 | 10.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL94461 | — | — | 1 | 10.05 |
| CHEMBL329007 | — | — | 1 | 9.96 |
| CHEMBL94328 | — | — | 1 | 9.85 |
| CHEMBL437075 | — | — | 1 | 9.85 |
| CHEMBL319301 | — | — | 1 | 9.74 |
| CHEMBL319118 | — | — | 1 | 9.72 |
| CHEMBL95852 | — | — | 1 | 9.39 |
| CHEMBL95315 | — | — | 1 | 9.34 |
| CHEMBL441225 | CP-99994 | — | 1 | 9.31 |
| CHEMBL98125 | — | — | 1 | 9.25 |
| CHEMBL235363 | SUBSTANCE P | 1.0 | 1 | 9.21 |
| CHEMBL320220 | — | — | 1 | 9.10 |
| CHEMBL327357 | — | — | 1 | 7.96 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL94461 | — | IC50 | = | 0.09 | nM | 10.05 |
| CHEMBL329007 | — | IC50 | = | 0.11 | nM | 9.96 |
| CHEMBL94328 | — | IC50 | = | 0.14 | nM | 9.85 |
| CHEMBL437075 | — | IC50 | = | 0.14 | nM | 9.85 |
| CHEMBL319301 | — | IC50 | = | 0.18 | nM | 9.74 |
| CHEMBL319118 | — | IC50 | = | 0.19 | nM | 9.72 |
| CHEMBL95852 | — | IC50 | = | 0.41 | nM | 9.39 |
| CHEMBL95315 | — | IC50 | = | 0.46 | nM | 9.34 |
| CHEMBL441225 | CP-99994 | IC50 | = | 0.49 | nM | 9.31 |
| CHEMBL98125 | — | IC50 | = | 0.56 | nM | 9.25 |
| CHEMBL235363 | SUBSTANCE P | IC50 | = | 0.61 | nM | 9.21 |
| CHEMBL320220 | — | IC50 | = | 0.8 | nM | 9.10 |
| CHEMBL327357 | — | IC50 | = | 10.87 | nM | 7.96 |