Assay Detail
Functional
CHEMBL807901
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antagonistic activity against human Tachykinin receptor 1
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
4,4-Disubstituted piperidines: a new class of NK1 antagonist.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 7.72 | 9.02 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL422931 | — | — | 1 | 9.02 |
| CHEMBL23617 | — | — | 1 | 8.34 |
| CHEMBL277918 | — | — | 1 | 8.05 |
| CHEMBL281828 | — | — | 1 | 7.24 |
| CHEMBL22680 | — | — | 1 | 5.96 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL422931 | — | IC50 | = | 0.95 | nM | 9.02 |
| CHEMBL23617 | — | IC50 | = | 4.6 | nM | 8.34 |
| CHEMBL277918 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL281828 | — | IC50 | = | 57.0 | nM | 7.24 |
| CHEMBL22680 | — | IC50 | = | 1100.0 | nM | 5.96 |