Assay Detail
Binding
CHEMBL807902
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Binding affinity against Gln165Ala mutant type human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | CHO |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Synthesis and biological evaluation of NK1 antagonists derived from L-tryptophan.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 7.85 | 8.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL420543 | — | — | 1 | 8.85 |
| CHEMBL173231 | — | — | 1 | 8.40 |
| CHEMBL174038 | — | — | 1 | 8.10 |
| CHEMBL22870 | L-732138 | — | 1 | 8.09 |
| CHEMBL173396 | — | — | 1 | 8.00 |
| CHEMBL120781 | — | — | 1 | 8.00 |
| CHEMBL16192 | CP-96345 | — | 1 | 7.66 |
| CHEMBL367034 | — | — | 1 | 5.68 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL420543 | — | IC50 | = | 1.4 | nM | 8.85 |
| CHEMBL173231 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL174038 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL22870 | L-732138 | IC50 | = | 8.1 | nM | 8.09 |
| CHEMBL173396 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL120781 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL16192 | CP-96345 | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL367034 | — | IC50 | = | 2100.0 | nM | 5.68 |