Assay Detail
Binding
CHEMBL807904
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Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.
23
Total Activities
23
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | CHO |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Synthesis and biological evaluation of NK1 antagonists derived from L-tryptophan.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 23 | 8.43 | 9.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL420543 | — | — | 1 | 9.77 |
| CHEMBL176500 | — | — | 1 | 9.52 |
| CHEMBL426577 | — | — | 1 | 9.43 |
| CHEMBL16192 | CP-96345 | — | 1 | 9.35 |
| CHEMBL175224 | — | — | 1 | 9.33 |
| CHEMBL441225 | CP-99994 | — | 1 | 9.30 |
| CHEMBL173396 | — | — | 1 | 9.30 |
| CHEMBL174016 | — | — | 1 | 9.22 |
| CHEMBL120081 | — | — | 1 | 9.22 |
| CHEMBL366818 | — | — | 1 | 9.15 |
| CHEMBL174038 | — | — | 1 | 9.05 |
| CHEMBL22870 | L-732138 | — | 1 | 8.80 |
| CHEMBL174526 | — | — | 1 | 8.74 |
| CHEMBL120781 | — | — | 1 | 8.51 |
| CHEMBL173231 | — | — | 1 | 8.46 |
| CHEMBL173564 | — | — | 1 | 8.42 |
| CHEMBL369601 | — | — | 1 | 8.30 |
| CHEMBL278351 | — | — | 1 | 7.66 |
| CHEMBL367034 | — | — | 1 | 7.28 |
| CHEMBL23129 | L-708568 | — | 1 | 7.17 |
| CHEMBL176557 | — | — | 1 | 6.12 |
| CHEMBL305608 | — | — | 1 | 5.99 |
| CHEMBL332796 | — | — | 1 | 5.83 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL420543 | — | IC50 | = | 0.17 | nM | 9.77 |
| CHEMBL176500 | — | IC50 | = | 0.3 | nM | 9.52 |
| CHEMBL426577 | — | IC50 | = | 0.37 | nM | 9.43 |
| CHEMBL16192 | CP-96345 | IC50 | = | 0.45 | nM | 9.35 |
| CHEMBL175224 | — | IC50 | = | 0.47 | nM | 9.33 |
| CHEMBL441225 | CP-99994 | IC50 | = | 0.5 | nM | 9.30 |
| CHEMBL173396 | — | IC50 | = | 0.5 | nM | 9.30 |
| CHEMBL174016 | — | IC50 | = | 0.6 | nM | 9.22 |
| CHEMBL120081 | — | IC50 | = | 0.6 | nM | 9.22 |
| CHEMBL366818 | — | IC50 | = | 0.7 | nM | 9.15 |
| CHEMBL174038 | — | IC50 | = | 0.9 | nM | 9.05 |
| CHEMBL22870 | L-732138 | IC50 | = | 1.6 | nM | 8.80 |
| CHEMBL174526 | — | IC50 | = | 1.8 | nM | 8.74 |
| CHEMBL120781 | — | IC50 | = | 3.1 | nM | 8.51 |
| CHEMBL173231 | — | IC50 | = | 3.5 | nM | 8.46 |
| CHEMBL173564 | — | IC50 | = | 3.8 | nM | 8.42 |
| CHEMBL369601 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL278351 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL367034 | — | IC50 | = | 53.0 | nM | 7.28 |
| CHEMBL23129 | L-708568 | IC50 | = | 67.0 | nM | 7.17 |
| CHEMBL176557 | — | IC50 | = | 767.0 | nM | 6.12 |
| CHEMBL305608 | — | IC50 | = | 1033.0 | nM | 5.99 |
| CHEMBL332796 | — | IC50 | = | 1467.0 | nM | 5.83 |