Assay Detail
Binding
CHEMBL807961
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.
37
Total Activities
37
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | CHO |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
4,4-Disubstituted piperidine high-affinity NK1 antagonists: structure-activity relationships and in vivo activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 37 | 8.24 | 9.62 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL143156 | — | — | 1 | 9.62 |
| CHEMBL424291 | — | — | 1 | 9.49 |
| CHEMBL143375 | — | — | 1 | 9.30 |
| CHEMBL357887 | — | — | 1 | 9.22 |
| CHEMBL141034 | — | — | 1 | 9.05 |
| CHEMBL143464 | — | — | 1 | 9.03 |
| CHEMBL422931 | — | — | 1 | 9.02 |
| CHEMBL27006 | — | — | 1 | 9.00 |
| CHEMBL332284 | — | — | 1 | 9.00 |
| CHEMBL341599 | — | — | 1 | 8.92 |
| CHEMBL142216 | — | — | 1 | 8.77 |
| CHEMBL139719 | — | — | 1 | 8.74 |
| CHEMBL140263 | — | — | 1 | 8.74 |
| CHEMBL337358 | — | — | 1 | 8.74 |
| CHEMBL143974 | — | — | 1 | 8.62 |
| CHEMBL264997 | — | — | 1 | 8.55 |
| CHEMBL140982 | — | — | 1 | 8.54 |
| CHEMBL141994 | — | — | 1 | 8.54 |
| CHEMBL359214 | — | — | 1 | 8.51 |
| CHEMBL23617 | — | — | 1 | 8.34 |
| CHEMBL139784 | — | — | 1 | 8.28 |
| CHEMBL341656 | — | — | 1 | 8.24 |
| CHEMBL143775 | — | — | 1 | 8.16 |
| CHEMBL341745 | — | — | 1 | 8.14 |
| CHEMBL277918 | — | — | 1 | 8.04 |
| CHEMBL139558 | — | — | 1 | 7.90 |
| CHEMBL442028 | — | — | 1 | 7.87 |
| CHEMBL139868 | — | — | 1 | 7.42 |
| CHEMBL336931 | — | — | 1 | 7.26 |
| CHEMBL281828 | — | — | 1 | 7.24 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL143156 | — | IC50 | = | 0.24 | nM | 9.62 |
| CHEMBL424291 | — | IC50 | = | 0.32 | nM | 9.49 |
| CHEMBL143375 | — | IC50 | = | 0.5 | nM | 9.30 |
| CHEMBL357887 | — | IC50 | = | 0.6 | nM | 9.22 |
| CHEMBL141034 | — | IC50 | = | 0.9 | nM | 9.05 |
| CHEMBL143464 | — | IC50 | = | 0.94 | nM | 9.03 |
| CHEMBL422931 | — | IC50 | = | 0.95 | nM | 9.02 |
| CHEMBL27006 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL332284 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL341599 | — | IC50 | = | 1.2 | nM | 8.92 |
| CHEMBL142216 | — | IC50 | = | 1.7 | nM | 8.77 |
| CHEMBL139719 | — | IC50 | = | 1.8 | nM | 8.74 |
| CHEMBL140263 | — | IC50 | = | 1.8 | nM | 8.74 |
| CHEMBL337358 | — | IC50 | = | 1.8 | nM | 8.74 |
| CHEMBL143974 | — | IC50 | = | 2.4 | nM | 8.62 |
| CHEMBL264997 | — | IC50 | = | 2.8 | nM | 8.55 |
| CHEMBL140982 | — | IC50 | = | 2.9 | nM | 8.54 |
| CHEMBL141994 | — | IC50 | = | 2.9 | nM | 8.54 |
| CHEMBL359214 | — | IC50 | = | 3.1 | nM | 8.51 |
| CHEMBL23617 | — | IC50 | = | 4.6 | nM | 8.34 |
| CHEMBL139784 | — | IC50 | = | 5.3 | nM | 8.28 |
| CHEMBL341656 | — | IC50 | = | 5.7 | nM | 8.24 |
| CHEMBL143775 | — | IC50 | = | 6.9 | nM | 8.16 |
| CHEMBL341745 | — | IC50 | = | 7.3 | nM | 8.14 |
| CHEMBL277918 | — | IC50 | = | 9.1 | nM | 8.04 |
| CHEMBL139558 | — | IC50 | = | 12.6 | nM | 7.90 |
| CHEMBL442028 | — | IC50 | = | 13.5 | nM | 7.87 |
| CHEMBL139868 | — | IC50 | = | 38.0 | nM | 7.42 |
| CHEMBL336931 | — | IC50 | = | 55.0 | nM | 7.26 |
| CHEMBL281828 | — | IC50 | = | 57.0 | nM | 7.24 |
| CHEMBL143813 | — | IC50 | = | 63.0 | nM | 7.20 |
| CHEMBL143377 | — | IC50 | = | 84.0 | nM | 7.08 |
| CHEMBL140101 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL358305 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL444339 | — | IC50 | = | 730.0 | nM | 6.14 |
| CHEMBL22680 | — | IC50 | = | 1113.0 | nM | 5.95 |
| CHEMBL342233 | — | IC50 | > | 100.0 | nM | - |