Assay Detail
Binding
CHEMBL807965
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Binding affinity towards Tachykinin receptor 1 in human IM-9 cells using [3H]-substance P as ligand
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | IM-9 |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
The discovery of (2S,3S)-cis-2-(diphenylmethyl)-N-[(2-methoxyphenyl)methyl]-1- azabicyclo[2.2.2]-octan-3-amine as a novel, nonpeptide substance P antagonisst.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 16 | 7.17 | 9.11 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL16192 | CP-96345 | — | 1 | 9.11 |
| CHEMBL346154 | — | — | 1 | 8.66 |
| CHEMBL89652 | — | — | 1 | 7.80 |
| CHEMBL431690 | — | — | 1 | 7.80 |
| CHEMBL315435 | — | — | 1 | 7.78 |
| CHEMBL86806 | — | — | 1 | 7.70 |
| CHEMBL282331 | — | — | 1 | 7.48 |
| CHEMBL419500 | — | — | 1 | 7.39 |
| CHEMBL86643 | — | — | 1 | 7.17 |
| CHEMBL86746 | — | — | 1 | 7.17 |
| CHEMBL89897 | — | — | 1 | 6.46 |
| CHEMBL86659 | — | — | 1 | 6.42 |
| CHEMBL86378 | — | — | 1 | 6.31 |
| CHEMBL433336 | — | — | 1 | 5.72 |
| CHEMBL315176 | — | — | 1 | 4.55 |
| CHEMBL85347 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL16192 | CP-96345 | IC50 | = | 0.77 | nM | 9.11 |
| CHEMBL346154 | — | IC50 | = | 2.2 | nM | 8.66 |
| CHEMBL89652 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL431690 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL315435 | — | IC50 | = | 16.7 | nM | 7.78 |
| CHEMBL86806 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL282331 | — | IC50 | = | 33.3 | nM | 7.48 |
| CHEMBL419500 | — | IC50 | = | 41.0 | nM | 7.39 |
| CHEMBL86643 | — | IC50 | = | 67.7 | nM | 7.17 |
| CHEMBL86746 | — | IC50 | = | 67.7 | nM | 7.17 |
| CHEMBL89897 | — | IC50 | = | 343.0 | nM | 6.46 |
| CHEMBL86659 | — | IC50 | = | 383.0 | nM | 6.42 |
| CHEMBL86378 | — | IC50 | = | 487.0 | nM | 6.31 |
| CHEMBL433336 | — | IC50 | = | 1890.0 | nM | 5.72 |
| CHEMBL315176 | — | IC50 | = | 28000.0 | nM | 4.55 |
| CHEMBL85347 | — | IC50 | > | 32000.0 | nM | - |