Assay Detail
Binding
CHEMBL807966
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Compound was tested in vitro for its Tachykinin receptor 1 affinity by the displacement of [125I]Bolton-Hunter substance p from human IM-9 cells
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | IM-9 |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
N-alkyl quinuclidinium substance P antagonists
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 7.95 | 9.28 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL16192 | CP-96345 | — | 1 | 9.28 |
| CHEMBL417263 | — | — | 1 | 8.89 |
| CHEMBL277524 | — | — | 1 | 7.91 |
| CHEMBL278487 | — | — | 1 | 7.65 |
| CHEMBL278455 | — | — | 1 | 7.49 |
| CHEMBL15970 | — | — | 1 | 6.48 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL16192 | CP-96345 | IC50 | = | 0.52 | nM | 9.28 |
| CHEMBL417263 | — | IC50 | = | 1.3 | nM | 8.89 |
| CHEMBL277524 | — | IC50 | = | 12.2 | nM | 7.91 |
| CHEMBL278487 | — | IC50 | = | 22.3 | nM | 7.65 |
| CHEMBL278455 | — | IC50 | = | 32.7 | nM | 7.49 |
| CHEMBL15970 | — | IC50 | = | 332.0 | nM | 6.48 |