Assay Detail
Binding
CHEMBL807969
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [125 I]-Tyr8 SP from the cloned human Tachykinin receptor 1 expressed in CHO cells
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
N-heteroaryl-2-phenyl-3-(benzyloxy)piperidines: a novel class of potent orally active human NK1 antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 8.95 | 10.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL99055 | — | — | 1 | 10.30 |
| CHEMBL99792 | — | — | 1 | 9.66 |
| CHEMBL441225 | CP-99994 | — | 1 | 9.30 |
| CHEMBL95626 | — | — | 1 | 9.28 |
| CHEMBL98811 | — | — | 1 | 9.10 |
| CHEMBL101763 | — | — | 1 | 9.05 |
| CHEMBL98022 | — | — | 1 | 9.01 |
| CHEMBL99873 | — | — | 1 | 9.00 |
| CHEMBL27003 | — | — | 1 | 8.89 |
| CHEMBL100141 | — | — | 1 | 7.44 |
| CHEMBL327736 | — | — | 1 | 7.37 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL99055 | — | IC50 | = | 0.05 | nM | 10.30 |
| CHEMBL99792 | — | IC50 | = | 0.22 | nM | 9.66 |
| CHEMBL441225 | CP-99994 | IC50 | = | 0.5 | nM | 9.30 |
| CHEMBL95626 | — | IC50 | = | 0.53 | nM | 9.28 |
| CHEMBL98811 | — | IC50 | = | 0.8 | nM | 9.10 |
| CHEMBL101763 | — | IC50 | = | 0.9 | nM | 9.05 |
| CHEMBL98022 | — | IC50 | = | 0.97 | nM | 9.01 |
| CHEMBL99873 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL27003 | — | IC50 | = | 1.3 | nM | 8.89 |
| CHEMBL100141 | — | IC50 | = | 36.0 | nM | 7.44 |
| CHEMBL327736 | — | IC50 | = | 43.0 | nM | 7.37 |