Assay Detail
Functional
CHEMBL808101
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Compound was tested for its inhibitory effect on the growth of T24 tumor cell line from bladder.
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | T-24 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Nucleosides and nucleotides. 152. 1-(3-C-Ethynyl--D-ribo-pentofuranosyl)uracil as a broad spectrum antitumor nucleoside
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 6.73 | 7.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL54918 | 5-FLUOROURIDINE | 2.0 | 1 | 7.85 |
| CHEMBL317514 | — | — | 1 | 7.47 |
| CHEMBL917 | FLOXURIDINE | 4.0 | 1 | 6.92 |
| CHEMBL185 | FLUOROURACIL | 4.0 | 1 | 4.66 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL54918 | 5-FLUOROURIDINE | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL317514 | — | IC50 | = | 34.0 | nM | 7.47 |
| CHEMBL917 | FLOXURIDINE | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL185 | FLUOROURACIL | IC50 | = | 22000.0 | nM | 4.66 |