Assay Detail
Binding
CHEMBL808105
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Inhibition of [3H](+)-DTG binding to Sigma opioid receptor (type 2) of rat liver membranes in the presence of (+)-pentazocine
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Subcellular | Membrane |
| Confidence | 3 — Cell-line / Tissue |
| Curated By | Expert |
Publication
Conformationally-flexible benzamide analogues as dopamine D3 and sigma 2 receptor ligands.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 14 | 7.50 | 8.09 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL291439 | — | — | 1 | 8.09 |
| CHEMBL60048 | — | — | 1 | 7.99 |
| CHEMBL64261 | — | — | 1 | 7.91 |
| CHEMBL64260 | — | — | 1 | 7.88 |
| CHEMBL64176 | — | — | 1 | 7.79 |
| CHEMBL60139 | — | — | 1 | 7.75 |
| CHEMBL60140 | — | — | 1 | 7.67 |
| CHEMBL53038 | — | — | 1 | 7.60 |
| CHEMBL61789 | — | — | 1 | 7.58 |
| CHEMBL60133 | — | — | 1 | 7.32 |
| CHEMBL62638 | — | — | 1 | 7.16 |
| CHEMBL59713 | — | — | 1 | 7.12 |
| CHEMBL64751 | — | — | 1 | 7.05 |
| CHEMBL305366 | — | — | 1 | 6.14 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL291439 | — | Ki | = | 8.2 | nM | 8.09 |
| CHEMBL60048 | — | Ki | = | 10.3 | nM | 7.99 |
| CHEMBL64261 | — | Ki | = | 12.4 | nM | 7.91 |
| CHEMBL64260 | — | Ki | = | 13.3 | nM | 7.88 |
| CHEMBL64176 | — | Ki | = | 16.4 | nM | 7.79 |
| CHEMBL60139 | — | Ki | = | 17.6 | nM | 7.75 |
| CHEMBL60140 | — | Ki | = | 21.2 | nM | 7.67 |
| CHEMBL53038 | — | Ki | = | 25.0 | nM | 7.60 |
| CHEMBL61789 | — | Ki | = | 26.4 | nM | 7.58 |
| CHEMBL60133 | — | Ki | = | 47.7 | nM | 7.32 |
| CHEMBL62638 | — | Ki | = | 70.0 | nM | 7.16 |
| CHEMBL59713 | — | Ki | = | 75.0 | nM | 7.12 |
| CHEMBL64751 | — | Ki | = | 89.4 | nM | 7.05 |
| CHEMBL305366 | — | Ki | = | 716.5 | nM | 6.14 |