Assay Detail
Binding
CHEMBL808314
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Inhibitory activity against influenza A virus sialidase
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Influenza A virus |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Neuraminidase (CHEMBL2051) ↗| Type | SINGLE PROTEIN |
| Organism | Influenza A virus (A/Puerto Rico/8/1934(H1N1)) |
Publication
Novel inhibitors of influenza sialidases related to zanamivir. Heterocyclic replacements of the glycerol sidechain
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 5.70 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL222813 | ZANAMIVIR | 4.0 | 1 | 8.70 |
| CHEMBL73669 | — | — | 1 | 8.70 |
| CHEMBL302133 | — | — | 1 | 7.16 |
| CHEMBL70936 | — | — | 1 | 6.48 |
| CHEMBL70627 | — | — | 1 | 4.92 |
| CHEMBL71078 | — | — | 1 | 4.92 |
| CHEMBL308831 | — | — | 1 | 4.85 |
| CHEMBL303175 | — | — | 1 | 4.64 |
| CHEMBL72024 | — | — | 1 | 4.25 |
| CHEMBL305240 | — | — | 1 | 4.06 |
| CHEMBL303919 | — | — | 1 | 4.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL222813 | ZANAMIVIR | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL73669 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL302133 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL70936 | — | IC50 | = | 330.0 | nM | 6.48 |
| CHEMBL70627 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL71078 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL308831 | — | IC50 | = | 14000.0 | nM | 4.85 |
| CHEMBL303175 | — | IC50 | = | 23000.0 | nM | 4.64 |
| CHEMBL72024 | — | IC50 | = | 56000.0 | nM | 4.25 |
| CHEMBL305240 | — | IC50 | = | 87000.0 | nM | 4.06 |
| CHEMBL303919 | — | IC50 | = | 99000.0 | nM | 4.00 |