Assay Detail
Binding
CHEMBL808318
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Compound was tested for its inhibitory activity against sialidase (influenza A virus by enzyme inhibition assay.).
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Influenza A virus |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Neuraminidase (CHEMBL2051) ↗| Type | SINGLE PROTEIN |
| Organism | Influenza A virus (A/Puerto Rico/8/1934(H1N1)) |
Publication
Dihydropyrancarboxamides related to zanamivir: a new series of inhibitors of influenza virus sialidases. 1. Discovery, synthesis, biological activity, and structure-activity relationships of 4-guanidino- and 4-amino-4H-pyran-6-carboxamides.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 7.48 | 8.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL164003 | — | — | 1 | 8.05 |
| CHEMBL430869 | — | — | 1 | 7.64 |
| CHEMBL1161504 | — | — | 1 | 7.28 |
| CHEMBL163966 | — | — | 1 | 6.96 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL164003 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL430869 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL1161504 | — | IC50 | = | 52.0 | nM | 7.28 |
| CHEMBL163966 | — | IC50 | = | 110.0 | nM | 6.96 |