Assay Detail
Binding
CHEMBL808464
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Inhibitory activity against Tissue plasminogen activator
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Design and synthesis of potent and selective macrocyclic thrombin inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 15 | 6.44 | 8.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL92615 | — | — | 1 | 8.52 |
| CHEMBL418965 | — | — | 1 | 8.22 |
| CHEMBL94952 | — | — | 1 | 8.22 |
| CHEMBL316901 | — | — | 1 | 7.70 |
| CHEMBL96354 | — | — | 1 | 6.82 |
| CHEMBL329266 | — | — | 1 | 6.44 |
| CHEMBL94864 | — | — | 1 | 6.32 |
| CHEMBL327421 | — | — | 1 | 6.19 |
| CHEMBL96599 | — | — | 1 | 5.50 |
| CHEMBL96801 | — | — | 1 | 5.41 |
| CHEMBL96376 | — | — | 1 | 5.37 |
| CHEMBL94622 | — | — | 1 | 5.25 |
| CHEMBL2204325 | — | — | 1 | 5.11 |
| CHEMBL93315 | — | — | 1 | 5.05 |
| CHEMBL329912 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL92615 | — | Ki | = | 3.0 | nM | 8.52 |
| CHEMBL418965 | — | Ki | = | 6.0 | nM | 8.22 |
| CHEMBL94952 | — | Ki | = | 6.0 | nM | 8.22 |
| CHEMBL316901 | — | Ki | = | 20.0 | nM | 7.70 |
| CHEMBL96354 | — | Ki | = | 150.0 | nM | 6.82 |
| CHEMBL329266 | — | Ki | = | 360.0 | nM | 6.44 |
| CHEMBL94864 | — | Ki | = | 480.0 | nM | 6.32 |
| CHEMBL327421 | — | Ki | = | 640.0 | nM | 6.19 |
| CHEMBL96599 | — | Ki | = | 3200.0 | nM | 5.50 |
| CHEMBL96801 | — | Ki | = | 3900.0 | nM | 5.41 |
| CHEMBL96376 | — | Ki | = | 4300.0 | nM | 5.37 |
| CHEMBL94622 | — | Ki | = | 5600.0 | nM | 5.25 |
| CHEMBL2204325 | — | Ki | = | 7700.0 | nM | 5.11 |
| CHEMBL93315 | — | Ki | = | 8900.0 | nM | 5.05 |
| CHEMBL329912 | — | Ki | = | 165000.0 | nM | - |