Assay Detail
Binding
CHEMBL808554
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Inhibition of recombinant steroid 5-alpha-reductase type I
26
Total Activities
25
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
3-oxo-5-alpha-steroid 4-dehydrogenase 1 (CHEMBL1787) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Structure-activity relationships for inhibition of type 1 and 2 human 5 alpha-reductase and human adrenal 3 beta-hydroxy-delta 5-steroid dehydrogenase/3-keto-delta 5-steroid isomerase by 6-azaandrost-4-en-3-ones: optimization of the C17 substituent.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 26 | 8.40 | 9.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2115222 | — | — | 2 | 9.70 |
| CHEMBL445627 | — | — | 1 | 9.70 |
| CHEMBL283123 | — | — | 1 | 9.52 |
| CHEMBL421735 | — | — | 1 | 9.30 |
| CHEMBL283430 | — | — | 1 | 9.22 |
| CHEMBL87805 | — | — | 1 | 8.89 |
| CHEMBL88032 | — | — | 1 | 8.82 |
| CHEMBL314309 | — | — | 1 | 8.52 |
| CHEMBL90440 | — | — | 1 | 8.51 |
| CHEMBL328670 | — | — | 1 | 8.47 |
| CHEMBL88485 | — | — | 1 | 8.44 |
| CHEMBL327702 | — | — | 1 | 8.40 |
| CHEMBL314725 | — | — | 1 | 8.38 |
| CHEMBL87082 | — | — | 1 | 8.34 |
| CHEMBL89327 | — | — | 1 | 8.30 |
| CHEMBL314977 | — | — | 1 | 8.28 |
| CHEMBL314953 | — | — | 1 | 8.17 |
| CHEMBL89557 | — | — | 1 | 8.17 |
| CHEMBL87021 | — | — | 1 | 8.12 |
| CHEMBL25516 | — | — | 1 | 8.10 |
| CHEMBL277224 | — | — | 1 | 8.06 |
| CHEMBL89240 | — | — | 1 | 7.58 |
| CHEMBL88494 | — | — | 1 | 7.57 |
| CHEMBL280155 | — | — | 1 | 6.62 |
| CHEMBL314069 | — | — | 1 | 5.96 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL445627 | — | Ki | = | 0.2 | nM | 9.70 |
| CHEMBL2115222 | — | Ki | = | 0.2 | nM | 9.70 |
| CHEMBL283123 | — | Ki | = | 0.3 | nM | 9.52 |
| CHEMBL421735 | — | Ki | = | 0.5 | nM | 9.30 |
| CHEMBL283430 | — | Ki | = | 0.6 | nM | 9.22 |
| CHEMBL2115222 | — | Ki | = | 0.6 | nM | 9.22 |
| CHEMBL87805 | — | Ki | = | 1.3 | nM | 8.89 |
| CHEMBL88032 | — | Ki | = | 1.5 | nM | 8.82 |
| CHEMBL314309 | — | Ki | = | 3.0 | nM | 8.52 |
| CHEMBL90440 | — | Ki | = | 3.1 | nM | 8.51 |
| CHEMBL328670 | — | Ki | = | 3.4 | nM | 8.47 |
| CHEMBL88485 | — | Ki | = | 3.6 | nM | 8.44 |
| CHEMBL327702 | — | Ki | = | 4.0 | nM | 8.40 |
| CHEMBL314725 | — | Ki | = | 4.2 | nM | 8.38 |
| CHEMBL87082 | — | Ki | = | 4.6 | nM | 8.34 |
| CHEMBL89327 | — | Ki | = | 5.0 | nM | 8.30 |
| CHEMBL314977 | — | Ki | = | 5.3 | nM | 8.28 |
| CHEMBL89557 | — | Ki | = | 6.7 | nM | 8.17 |
| CHEMBL314953 | — | Ki | = | 6.8 | nM | 8.17 |
| CHEMBL87021 | — | Ki | = | 7.5 | nM | 8.12 |
| CHEMBL25516 | — | Ki | = | 8.0 | nM | 8.10 |
| CHEMBL277224 | — | Ki | = | 8.8 | nM | 8.06 |
| CHEMBL89240 | — | Ki | = | 26.0 | nM | 7.58 |
| CHEMBL88494 | — | Ki | = | 27.0 | nM | 7.57 |
| CHEMBL280155 | — | Ki | = | 240.0 | nM | 6.62 |
| CHEMBL314069 | — | Ki | = | 1100.0 | nM | 5.96 |