Assay Detail
Binding
CHEMBL808555
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Apparent inhibition constant towards human Steroid 5-alpha-reductase type I
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
3-oxo-5-alpha-steroid 4-dehydrogenase 1 (CHEMBL1787) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
A non-steroidal diene acid inhibitor of human type 2 stereoid 5-reductase
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 8 | 6.19 | 7.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL279417 | — | — | 1 | 7.70 |
| CHEMBL710 | FINASTERIDE | 4.0 | 1 | 7.00 |
| CHEMBL138225 | EPRISTERIDE | 2.0 | 1 | 6.39 |
| CHEMBL308806 | — | — | 1 | 5.92 |
| CHEMBL449649 | — | — | 1 | 5.72 |
| CHEMBL76998 | — | — | 1 | 5.72 |
| CHEMBL310915 | — | — | 1 | 5.72 |
| CHEMBL78060 | — | — | 1 | 5.31 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL279417 | — | Ki | = | 20.0 | nM | 7.70 |
| CHEMBL710 | FINASTERIDE | Ki | = | 100.0 | nM | 7.00 |
| CHEMBL138225 | EPRISTERIDE | Ki | = | 410.0 | nM | 6.39 |
| CHEMBL308806 | — | Ki | = | 1200.0 | nM | 5.92 |
| CHEMBL449649 | — | Ki | = | 1900.0 | nM | 5.72 |
| CHEMBL76998 | — | Ki | = | 1900.0 | nM | 5.72 |
| CHEMBL310915 | — | Ki | = | 1900.0 | nM | 5.72 |
| CHEMBL78060 | — | Ki | = | 4900.0 | nM | 5.31 |