Assay Detail
Binding
CHEMBL808565
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro inhibitory activity against human Steroid 5-alpha-reductase type 1 in COS-1 cells was determined
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | COS-1 |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
3-oxo-5-alpha-steroid 4-dehydrogenase 1 (CHEMBL1787) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Synthesis and 5 alpha-reductase inhibitory activities of benzofuran derivatives with a carbamoyl group.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 7.29 | 8.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL25083 | — | — | 1 | 8.52 |
| CHEMBL153258 | — | — | 1 | 7.30 |
| CHEMBL152401 | — | — | 1 | 7.21 |
| CHEMBL155094 | — | — | 1 | 6.89 |
| CHEMBL155568 | — | — | 1 | 6.51 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL25083 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL153258 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL152401 | — | IC50 | = | 62.0 | nM | 7.21 |
| CHEMBL155094 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL155568 | — | IC50 | = | 310.0 | nM | 6.51 |