Assay Detail
Binding
CHEMBL808568
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro inhibitory concentration required to inhibit Steroid 5-alpha-reductase type 1 in cultured Hs 68 human foreskin fibroblast cells
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | Fibroblast |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
3-oxo-5-alpha-steroid 4-dehydrogenase 1 (CHEMBL1787) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
QSAR study of benzoquinolinones as inhibitors of human type 1 5--reductase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 16 | 7.04 | 8.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL279131 | — | — | 1 | 8.10 |
| CHEMBL279417 | — | — | 1 | 7.49 |
| CHEMBL15917 | — | — | 1 | 7.49 |
| CHEMBL279420 | — | — | 1 | 7.49 |
| CHEMBL278957 | — | — | 1 | 7.46 |
| CHEMBL278981 | — | — | 1 | 7.46 |
| CHEMBL16494 | — | — | 1 | 7.22 |
| CHEMBL439910 | — | — | 1 | 7.10 |
| CHEMBL439908 | — | — | 1 | 7.05 |
| CHEMBL16027 | — | — | 1 | 6.94 |
| CHEMBL16330 | — | — | 1 | 6.94 |
| CHEMBL16152 | — | — | 1 | 6.82 |
| CHEMBL16456 | — | — | 1 | 6.76 |
| CHEMBL277091 | — | — | 1 | 6.25 |
| CHEMBL278049 | — | — | 1 | 6.00 |
| CHEMBL16248 | — | — | 1 | 6.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL279131 | — | IC50 | = | 7.943 | nM | 8.10 |
| CHEMBL279417 | — | IC50 | = | 32.36 | nM | 7.49 |
| CHEMBL15917 | — | IC50 | = | 32.36 | nM | 7.49 |
| CHEMBL279420 | — | IC50 | = | 32.36 | nM | 7.49 |
| CHEMBL278957 | — | IC50 | = | 34.67 | nM | 7.46 |
| CHEMBL278981 | — | IC50 | = | 34.67 | nM | 7.46 |
| CHEMBL16494 | — | IC50 | = | 60.26 | nM | 7.22 |
| CHEMBL439910 | — | IC50 | = | 79.43 | nM | 7.10 |
| CHEMBL439908 | — | IC50 | = | 89.13 | nM | 7.05 |
| CHEMBL16027 | — | IC50 | = | 114.82 | nM | 6.94 |
| CHEMBL16330 | — | IC50 | = | 114.82 | nM | 6.94 |
| CHEMBL16152 | — | IC50 | = | 151.36 | nM | 6.82 |
| CHEMBL16456 | — | IC50 | = | 173.78 | nM | 6.76 |
| CHEMBL277091 | — | IC50 | = | 562.34 | nM | 6.25 |
| CHEMBL278049 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL16248 | — | IC50 | = | 1000.0 | nM | 6.00 |