Assay Detail
Binding
CHEMBL808764
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of src kinase
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Proto-oncogene tyrosine-protein kinase Src (CHEMBL267) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
(S)-13-[(dimethylamino)methyl]-10,11,14,15-tetrahydro-4,9:16, 21-dimetheno-1H, 13H-dibenzo[e,k]pyrrolo[3,4-h][1,4,13]oxadiazacyclohexadecene-1,3(2H)-d ione (LY333531) and related analogues: isozyme selective inhibitors of protein kinase C beta.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 6.00 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL388978 | STAUROSPORINE | — | 1 | 9.00 |
| CHEMBL419866 | — | — | 1 | 4.96 |
| CHEMBL316239 | — | — | 1 | 4.05 |
| CHEMBL311543 | — | — | 1 | - |
| CHEMBL328229 | — | — | 1 | - |
| CHEMBL315389 | — | — | 1 | - |
| CHEMBL292495 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL388978 | STAUROSPORINE | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL419866 | — | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL316239 | — | IC50 | = | 89000.0 | nM | 4.05 |
| CHEMBL311543 | — | IC50 | = | - | nM | - |
| CHEMBL328229 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL315389 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL292495 | — | IC50 | > | 100000.0 | nM | - |